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KMID : 0043320200430121259
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Archives of Pharmacal Research
2020 Volume.43 No. 12 p.1259 ~ p.1275
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Pharmacological effects of harmine and its derivatives: a review
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Zhang Liang
Li Dengchang
Yu Shenglan
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Abstract
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Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has been used for thousands of years in the Middle East and China. Harmine has many pharmacological activities including anti-inflammatory, neuroprotective, antidiabetic, and antitumor activities. Moreover, harmine exhibits insecticidal, antiviral, and antibacterial effects. Harmine derivatives exhibit pharmacological effects similar to those of harmine, but with better antitumor activity and low neurotoxicity. Many studies have been conducted on the pharmacological activities of harmine and harmine derivatives. This article reviews the pharmacological effects and associated mechanisms of harmine. In addition, the structure?activity relationship of harmine derivatives has been summarized.
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KEYWORD
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Harmine, Derivatives, Pharmacological effects, Neuroprotective effects, Antidiabetic, Anti-tumor
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